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Two single-point mutations in Ankyrin Repeat one drastically change the threshold temperature of TRPV1

TRPV1 plays an important role in the thermosensory system; however, the mechanism controlling its heat activation property is not well understood. Here, we determine the heat activation properties of TRPV1 cloned from tailed amphibians, which prefer cooler environments, finding the threshold tempera...

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Detalles Bibliográficos
Autores principales: Hori, Shogo, Tateyama, Michihiro, Shirai, Tsuyoshi, Kubo, Yoshihiro, Saitoh, Osamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10175561/
https://www.ncbi.nlm.nih.gov/pubmed/37169739
http://dx.doi.org/10.1038/s41467-023-38051-1