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The hyperinflammatory spectrum: from defects in cytotoxicity to cytokine control

Cytotoxic lymphocytes kill target cells through polarized release of the content of cytotoxic granules towards the target cell. The importance of this cytotoxic pathway in immune regulation is evidenced by the severe and often fatal condition, known as hemophagocytic lymphohistiocytosis (HLH) that o...

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Detalles Bibliográficos
Autores principales: Planas, Raquel, Felber, Matthias, Vavassori, Stefano, Pachlopnik Schmid, Jana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10175623/
https://www.ncbi.nlm.nih.gov/pubmed/37187762
http://dx.doi.org/10.3389/fimmu.2023.1163316