PepSim: T-cell cross-reactivity prediction via comparison of peptide sequence and peptide-HLA structure

INTRODUCTION: Peptide-HLA class I (pHLA) complexes on the surface of tumor cells can be targeted by cytotoxic T-cells to eliminate tumors, and this is one of the bases for T-cell-based immunotherapies. However, there exist cases where therapeutic T-cells directed towards tumor pHLA complexes may als...

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Detalles Bibliográficos
Autores principales: Hall-Swan, Sarah, Slone, Jared, Rigo, Mauricio M., Antunes, Dinler A., Lizée, Gregory, Kavraki, Lydia E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10175663/
https://www.ncbi.nlm.nih.gov/pubmed/37187737
http://dx.doi.org/10.3389/fimmu.2023.1108303

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10175663/
https://www.ncbi.nlm.nih.gov/pubmed/37187737
http://dx.doi.org/10.3389/fimmu.2023.1108303

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