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Stress resilience-enhancing drugs preserve tissue structure and function in degenerating retina via phosphodiesterase inhibition
Chronic, progressive retinal diseases, such as age-related macular degeneration (AMD), diabetic retinopathy, and retinitis pigmentosa, arise from genetic and environmental perturbations of cellular and tissue homeostasis. These disruptions accumulate with repeated exposures to stress over time, lead...
Autores principales: | C. Luu, Jennings, Saadane, Aicha, Leinonen, Henri, H. Choi, Elliot, Gao, Fangyuan, Lewandowski, Dominik, Halabi, Maximilian, L. Sander, Christopher, Wu, Arum, Wang, Jacob M., Singh, Rupesh, Gao, Songqi, Lessieur, Emma M., Dong, Zhiqian, Palczewska, Grazyna, Mullins, Robert F., Peachey, Neal S., Kiser, Philip D., Tabaka, Marcin, Kern, Timothy S., Palczewski, Krzysztof |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10175720/ https://www.ncbi.nlm.nih.gov/pubmed/37126699 http://dx.doi.org/10.1073/pnas.2221045120 |
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