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Epigenetic silencing of selected hypothalamic neuropeptides in narcolepsy with cataplexy

Narcolepsy with cataplexy is a sleep disorder caused by deficiency in the hypothalamic neuropeptide hypocretin/orexin (HCRT), unanimously believed to result from autoimmune destruction of hypocretin-producing neurons. HCRT deficiency can also occur in secondary forms of narcolepsy and be only tempor...

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Detalles Bibliográficos
Autores principales: Seifinejad, Ali, Ramosaj, Mergim, Shan, Ling, Li, Sha, Possovre, Marie-Laure, Pfister, Corinne, Fronczek, Rolf, Garrett-Sinha, Lee A., Frieser, David, Honda, Makoto, Arribat, Yoan, Grepper, Dogan, Amati, Francesca, Picot, Marie, Agnoletto, Andrea, Iseli, Christian, Chartrel, Nicolas, Liblau, Roland, Lammers, Gert J., Vassalli, Anne, Tafti, Mehdi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10175817/
https://www.ncbi.nlm.nih.gov/pubmed/37126681
http://dx.doi.org/10.1073/pnas.2220911120