CRISPR editing of CCR5 and HIV-1 facilitates viral elimination in antiretroviral drug-suppressed virus-infected humanized mice

Treatment of HIV-1(ADA)-infected CD34+ NSG-humanized mice with long-acting ester prodrugs of cabotegravir, lamivudine, and abacavir in combination with native rilpivirine was followed by dual CRISPR-Cas9 C-C chemokine receptor type five (CCR5) and HIV-1 proviral DNA gene editing. This led to sequent...

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Detalles Bibliográficos
Autores principales: Dash, Prasanta K., Chen, Chen, Kaminski, Rafal, Su, Hang, Mancuso, Pietro, Sillman, Brady, Zhang, Chen, Liao, Shuren, Sravanam, Sruthi, Liu, Hong, Waight, Emiko, Guo, Lili, Mathews, Saumi, Sariyer, Rahsan, Mosley, R. Lee, Poluektova, Larisa Y., Caocci, Maurizio, Amini, Shohreh, Gorantla, Santhi, Burdo, Tricia H., Edagwa, Benson, Gendelman, Howard E., Khalili, Kamel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10175831/
https://www.ncbi.nlm.nih.gov/pubmed/37126704
http://dx.doi.org/10.1073/pnas.2217887120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10175831/
https://www.ncbi.nlm.nih.gov/pubmed/37126704
http://dx.doi.org/10.1073/pnas.2217887120

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