Concentration QTc analysis of giredestrant: Overcoming QT/heart rate confounding in the presence of drug‐induced heart rate changes

Concentration‐QTc (C‐QTc) analysis has become a common approach for evaluating proarrhythmic risk and delayed cardiac repolarization of oncology drug candidates. Significant heart rate (HR) change has been associated with certain classes of oncology drugs and can result in over‐ or underestimation o...

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Detalles Bibliográficos
Autores principales: Brooks, Logan, Dolton, Michael, Langenhorst, Jurgen, Yoshida, Kenta, Lien, Yi Ting (Kayla), Malhi, Vikram, Li, Chunze, Perez‐Moreno, Pablo, Bond, John, Chen, Ya‐Chi, Yu, Jiajie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10175970/
https://www.ncbi.nlm.nih.gov/pubmed/36772881
http://dx.doi.org/10.1111/cts.13491

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10175970/
https://www.ncbi.nlm.nih.gov/pubmed/36772881
http://dx.doi.org/10.1111/cts.13491

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