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Trigeminal nerve-derived substance P regulates limbal stem cells by the PI3K-AKT pathway

Trigeminal nerve-derived substance P (SP), a widespread neuropeptide, is known to maintain the corneal epithelial homeostasis and promote the closure of wound healing. Using comprehensive in vivo and in vitro assays and RNA-sequencing analysis, we aimed to unveil the positive effects of SP on the bi...

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Detalles Bibliográficos
Autores principales: Xu, Peipei, Lin, Xiongshi, Dong, Xing, Liu, Ying, Wang, Zhichong, Wang, Shuangyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10176256/
https://www.ncbi.nlm.nih.gov/pubmed/37187698
http://dx.doi.org/10.1016/j.isci.2023.106688