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Laminin switches terminal differentiation fate of human trophoblast stem cells under chemically defined culture conditions

Human trophoblast stem cells (hTSCs) have emerged as a powerful tool to model early placental development in vitro. Analogous to the epithelial cytotrophoblast in the placenta, hTSCs can differentiate into cells of the extravillous trophoblast (EVT) lineage or the multinucleate syncytiotrophoblast (...

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Detalles Bibliográficos
Autores principales: Karakis, Victoria, Jabeen, Mahe, Britt, John W., Cordiner, Abigail, Mischler, Adam, Li, Feng, San Miguel, Adriana, Rao, Balaji M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10176266/
https://www.ncbi.nlm.nih.gov/pubmed/36972789
http://dx.doi.org/10.1016/j.jbc.2023.104650