A simple and efficient synthesis of N-[3-chloro-4-(4-chlorophenoxy)-phenyl]-2-hydroxy-3,5-diiodobenzamide, rafoxanide

A method for the synthesis of rafoxanide 6, a halogenated salicylanilide used as an efficient anthelmintic in sheep and cattle, is presented. Rafoxanide 6 was synthesized in only three steps from readily available 4-chlorophenol with 74% overall yield. The synthesis has two key stages: the first was...

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Detalles Bibliográficos
Autores principales: Kesternich, Víctor, Pérez-Fehrmann, Marcia, Quezada, Víctor, Castroagudín, Mariña, Nelson, Ronald, Martínez, Rolando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Versita 2023
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10176281/
https://www.ncbi.nlm.nih.gov/pubmed/37362790
http://dx.doi.org/10.1007/s11696-023-02846-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10176281/
https://www.ncbi.nlm.nih.gov/pubmed/37362790
http://dx.doi.org/10.1007/s11696-023-02846-9

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