Role of CD14+ monocyte-derived oxidised mitochondrial DNA in the inflammatory interferon type 1 signature in juvenile dermatomyositis

OBJECTIVES: To define the host mechanisms contributing to the pathological interferon (IFN) type 1 signature in Juvenile dermatomyositis (JDM). METHODS: RNA-sequencing was performed on CD4(+), CD8(+), CD14(+) and CD19(+) cells sorted from pretreatment and on-treatment JDM (pretreatment n=10, on-trea...

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Detalles Bibliográficos
Autores principales: Wilkinson, Meredyth G Ll, Moulding, Dale, McDonnell, Thomas C R, Orford, Michael, Wincup, Chris, Ting, Joanna Y J, Otto, Georg W, Restuadi, Restuadi, Kelberman, Daniel, Papadopoulou, Charalampia, Castellano, Sergi, Eaton, Simon, Deakin, Claire T, Rosser, Elizabeth C, Wedderburn, Lucy R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Myositis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10176342/
https://www.ncbi.nlm.nih.gov/pubmed/36564154
http://dx.doi.org/10.1136/ard-2022-223469

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10176342/
https://www.ncbi.nlm.nih.gov/pubmed/36564154
http://dx.doi.org/10.1136/ard-2022-223469

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