Microglia activation in the presence of intact blood–brain barrier and disruption of hippocampal neurogenesis via IL-6 and IL-18 mediate early diffuse neuropsychiatric lupus

INTRODUCTION: Inflammatory mediators are detected in the cerebrospinal fluid of systemic lupus erythematosus patients with central nervous system involvement (NPSLE), yet the underlying cellular and molecular mechanisms leading to neuropsychiatric disease remain elusive. METHODS: We performed a comp...

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Detalles Bibliográficos
Autores principales: Nikolopoulos, Dionysis, Manolakou, Theodora, Polissidis, Alexia, Filia, Anastasia, Bertsias, George, Koutmani, Yassemi, Boumpas, Dimitrios T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Systemic Lupus Erythematosus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10176423/
https://www.ncbi.nlm.nih.gov/pubmed/36898766
http://dx.doi.org/10.1136/ard-2022-223506

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10176423/
https://www.ncbi.nlm.nih.gov/pubmed/36898766
http://dx.doi.org/10.1136/ard-2022-223506

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