Engaging a Non-catalytic Cysteine Residue Drives Potent and Selective Inhibition of Caspase-6

[Image: see text] Caspases are a family of cysteine-dependent proteases with important cellular functions in inflammation and apoptosis, while also implicated in human diseases. Classical chemical tools to study caspase functions lack selectivity for specific caspase family members due to highly con...

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Detalles Bibliográficos
Autores principales: Van Horn, Kurt S., Wang, Dongju, Medina-Cleghorn, Daniel, Lee, Peter S., Bryant, Clifford, Altobelli, Chad, Jaishankar, Priyadarshini, Leung, Kevin K., Ng, Raymond A., Ambrose, Andrew J., Tang, Yinyan, Arkin, Michelle R., Renslo, Adam R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10176470/
https://www.ncbi.nlm.nih.gov/pubmed/37104712
http://dx.doi.org/10.1021/jacs.2c12240

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10176470/
https://www.ncbi.nlm.nih.gov/pubmed/37104712
http://dx.doi.org/10.1021/jacs.2c12240

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