Pyrrolysine-Inspired in Cellulo Synthesis of an Unnatural Amino Acid for Facile Macrocyclization of Proteins

[Image: see text] Macrocyclization has been touted as an effective strategy to enhance the in vivo stability and efficacy of protein therapeutics. Herein, we describe a scalable and robust system based on the endogenous biosynthesis of a noncanonical amino acid coupled to the pyrrolysine translation...

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Detalles Bibliográficos
Autores principales: Tai, Jingxuan, Wang, Lin, Chan, Wai Shan, Cheng, Jiahui, Chan, Yuk Hei, Lee, Marianne M., Chan, Michael K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10176472/
https://www.ncbi.nlm.nih.gov/pubmed/37125745
http://dx.doi.org/10.1021/jacs.3c01291

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10176472/
https://www.ncbi.nlm.nih.gov/pubmed/37125745
http://dx.doi.org/10.1021/jacs.3c01291

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