Cargando…

Functional Characterisation of the Circular RNA, circHTT(2-6), in Huntington’s Disease

Trinucleotide repeat disorders comprise ~20 severe, inherited, human neuromuscular and neurodegenerative disorders, which result from an abnormal expansion of repetitive sequences in the DNA. The most common of these, Huntington’s disease (HD), results from expansion of the CAG repeat region in exon...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gantley, Laura, Stringer, Brett W., Conn, Vanessa M., Ootsuka, Youichirou, Holds, Duncan, Slee, Mark, Aliakbari, Kamelya, Kirk, Kirsty, Ormsby, Rebecca J., Webb, Stuart T., Hanson, Adrienne, Lin, He, Selth, Luke A., Conn, Simon J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10177161/ https://www.ncbi.nlm.nih.gov/pubmed/37174737 http://dx.doi.org/10.3390/cells12091337

Ejemplares similares

Circular RNAs: Non-Canonical Observations on Non-Canonical RNAs
por: Stringer, Brett W., et al.
Publicado: (2023)

HTT haplogroups in Finnish patients with Huntington disease
por: Ylönen, Susanna, et al.
Publicado: (2019)

Parkinsonism with a Hint of Huntington’s from 29 CAG Repeats in HTT
por: JOT, Sipilä
Publicado: (2019)

Huntington’s Disease—An Outlook on the Interplay of the HTT Protein, Microtubules and Actin Cytoskeletal Components
por: Taran, Aleksandra S., et al.
Publicado: (2020)

In silico designing of putative peptides for targeting pathological protein Htt in Huntington's disease
por: Kohli, Harleen, et al.
Publicado: (2021)

A novel and accurate full-length HTT mouse model for Huntington’s disease
por: Shenoy, Sushila A, et al.
Publicado: (2022)

Alternative processing of human HTT mRNA with implications for Huntington’s disease therapeutics
por: Fienko, Sandra, et al.
Publicado: (2022)

FAN1 modifies Huntington’s disease progression by stabilizing the expanded HTT CAG repeat
por: Goold, Robert, et al.
Publicado: (2019)

The pathogenic exon 1 HTT protein is produced by incomplete splicing in Huntington’s disease patients
por: Neueder, Andreas, et al.
Publicado: (2017)

Targeting Gpr52 lowers mutant HTT levels and rescues Huntington’s disease-associated phenotypes
por: Song, Haikun, et al.
Publicado: (2018)

Integrated analysis on transcriptome and behaviors defines HTT repeat-dependent network modules in Huntington's disease
por: Huang, Lulin, et al.
Publicado: (2021)

Control of cutaneous blood flow by central nervous system
por: Ootsuka, Youichirou, et al.
Publicado: (2015)

Activation of the habenula complex evokes autonomic physiological responses similar to those associated with emotional stress
por: Ootsuka, Youichirou, et al.
Publicado: (2015)

Timing of activities of daily life is jaggy: How episodic ultradian changes in body and brain temperature are integrated into this process
por: Blessing, William, et al.
Publicado: (2016)

Intrastriatal Administration of AAV5-miHTT in Non-Human Primates and Rats Is Well Tolerated and Results in miHTT Transgene Expression in Key Areas of Huntington Disease Pathology
por: Spronck, Elisabeth A., et al.
Publicado: (2021)

Frequency of the loss of CAA interruption in the HTT CAG tract and implications for Huntington disease in the reduced penetrance range
por: Findlay Black, Hailey, et al.
Publicado: (2020)

An alternative splicing modulator decreases mutant HTT and improves the molecular fingerprint in Huntington’s disease patient neurons
por: Krach, Florian, et al.
Publicado: (2022)

SRRM4 Expands the Repertoire of Circular RNAs by Regulating Microexon Inclusion
por: Conn, Vanessa M., et al.
Publicado: (2020)

Chitosan-genipin nanohydrogel as a vehicle for sustained delivery of alpha-1 antitrypsin
por: Ghasemi, Ahmad, et al.
Publicado: (2015)

Developmental Trajectory of Height, Weight, and BMI in Children and Adolescents at Risk for Huntington’s Disease: Effect of mHTT on Growth
por: Tereshchenko, Alexander, et al.
Publicado: (2020)

Lateral habenula regulation of emotional hyperthermia: mediation via the medullary raphé
por: Ootsuka, Youichirou, et al.
Publicado: (2017)

Htt(Q111/+) Huntington’s Disease Knock-in Mice Exhibit Brain Region-Specific Morphological Changes and Synaptic Dysfunction
por: Kovalenko, Marina, et al.
Publicado: (2018)

Spanish HTT gene study reveals haplotype and allelic diversity with possible implications for germline expansion dynamics in Huntington disease
por: Ruiz de Sabando, Ainara, et al.
Publicado: (2022)

Identification of a HTT-specific binding motif in DNAJB1 essential for suppression and disaggregation of HTT
por: Ayala Mariscal, S. M., et al.
Publicado: (2022)

Attenuated cold defense responses in orexin neuron-ablated rats
por: Mohammed, Mazher, et al.
Publicado: (2016)

Body Temperature Measurements for Metabolic Phenotyping in Mice
por: Meyer, Carola W., et al.
Publicado: (2017)

AAV5-miHTT Gene Therapy Demonstrates Sustained Huntingtin Lowering and Functional Improvement in Huntington Disease Mouse Models
por: Spronck, Elisabeth A., et al.
Publicado: (2019)

Excess Rab4 rescues synaptic and behavioral dysfunction caused by defective HTT-Rab4 axonal transport in Huntington’s disease
por: White, Joseph A., et al.
Publicado: (2020)

Activating dopamine D2 receptors reduces brown adipose tissue thermogenesis induced by psychological stress and by activation of the lateral habenula
por: Brizuela, Mariana, et al.
Publicado: (2019)

HTT-DB: new features and updates
por: Dotto, Bruno Reis, et al.
Publicado: (2018)

Motivational, proteostatic and transcriptional deficits precede synapse loss, gliosis and neurodegeneration in the B6.Htt(Q111/+) model of Huntington’s disease
por: Bragg, Robert M., et al.
Publicado: (2017)

Peripheral huntingtin silencing does not ameliorate central signs of disease in the B6.Htt(Q111/+) mouse model of Huntington’s disease
por: Coffey, Sydney R., et al.
Publicado: (2017)

Robust Preimplantation Genetic Testing of Huntington Disease by Combined Triplet-Primed PCR Analysis of the HTT CAG Repeat and Multi-Microsatellite Haplotyping
por: Zhao, Mingjue, et al.
Publicado: (2019)

Clozapine, chlorpromazine and risperidone dose-dependently reduce emotional hyperthermia, a biological marker of salience
por: Blessing, William W., et al.
Publicado: (2017)

Characterization of HTT Inclusion Size, Location, and Timing in the zQ175 Mouse Model of Huntington´s Disease: An In Vivo High-Content Imaging Study
por: Carty, Nikisha, et al.
Publicado: (2015)

Comparison of mHTT Antibodies in Huntington’s Disease Mouse Models Reveal Specific Binding Profiles and Steady-State Ubiquitin Levels with Disease Development
por: Bayram-Weston, Zubeyde, et al.
Publicado: (2016)

AAV5-miHTT gene therapy demonstrates suppression of mutant huntingtin aggregation and neuronal dysfunction in a rat model of Huntington’s disease
por: Miniarikova, J, et al.
Publicado: (2017)

Corrigendum: Motivational, proteostatic and transcriptional deficits precede synapse loss, gliosis and neurodegeneration in the B6.Htt(Q111/+) model of Huntington’s disease
por: Bragg, Robert M., et al.
Publicado: (2017)

Investigation of intermediate CAG alleles of the HTT in the general population of Rio de Janeiro, Brazil, in comparison with a sample of Huntington disease‐affected families
por: Apolinário, Thays A., et al.
Publicado: (2020)

5-HTT independent effects of fluoxetine on neuroplasticity
por: Levy, Marion J. F., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_rn4hurg0sdr07q9u4nu7e2taio