Cargando…
Novel Therapeutic Target Critical for SARS-CoV-2 Infectivity and Induction of the Cytokine Release Syndrome
We discovered a novel therapeutic target critical for SARS-CoV-2, cellular infectivity and the induction of the cytokine release syndrome. Here, we show that the mammalian enzyme neuraminidase-1 (Neu-1) is part of a highly conserved signaling platform that regulates the dimerization and activation o...
Autores principales: | Harless, William W., Lewis, Beth, Qorri, Bessi, Abdulkhalek, Samar, Szewczuk, Myron R. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10177205/ https://www.ncbi.nlm.nih.gov/pubmed/37174732 http://dx.doi.org/10.3390/cells12091332 |
Ejemplares similares
-
Next Generation of Cancer Drug Repurposing: Therapeutic Combination of Aspirin and Oseltamivir Phosphate Potentiates Gemcitabine to Disable Key Survival Pathways Critical for Pancreatic Cancer Progression
por: Qorri, Bessi, et al.
Publicado: (2022) -
Novel Molecular Mechanism of Aspirin and Celecoxib Targeting Mammalian Neuraminidase-1 Impedes Epidermal Growth Factor Receptor Signaling Axis and Induces Apoptosis in Pancreatic Cancer Cells
por: Qorri, Bessi, et al.
Publicado: (2020) -
Repositioning of Old Drugs for Novel Cancer Therapies: Continuous Therapeutic Perfusion of Aspirin and Oseltamivir Phosphate with Gemcitabine Treatment Disables Tumor Progression, Chemoresistance, and Metastases
por: Qorri, Bessi, et al.
Publicado: (2022) -
Alternative therapies for metastatic breast cancer: multimodal approach targeting tumor cell heterogeneity
por: Sambi, Manpreet, et al.
Publicado: (2017) -
A Triple Combination of Metformin, Acetylsalicylic Acid, and Oseltamivir Phosphate Impacts Tumour Spheroid Viability and Upends Chemoresistance in Triple-Negative Breast Cancer
por: Sambi, Manpreet, et al.
Publicado: (2020)