Cargando…

Protein Levels of Anti-Apoptotic Mcl-1 and the Deubiquitinase USP9x Are Cooperatively Upregulated during Prostate Cancer Progression and Limit Response of Prostate Cancer Cells to Radiotherapy

SIMPLE SUMMARY: Radiotherapy constitutes an important therapeutic option for prostate cancer. However, prostate cancer cells often acquire resistance during cancer progression, limiting the cytotoxic effects of radiotherapy. Among factors regulating sensitivity to radiotherapy are members of the Bcl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hogh-Binder, Sophia A., Klein, Diana, Wolfsperger, Frederik, Huber, Stephan M., Hennenlotter, Jörg, Stenzl, Arnulf, Rudner, Justine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10177233/ https://www.ncbi.nlm.nih.gov/pubmed/37173959 http://dx.doi.org/10.3390/cancers15092496

Ejemplares similares

Deubiquitylating enzyme USP9x regulates radiosensitivity in glioblastoma cells by Mcl-1-dependent and -independent mechanisms
por: Wolfsperger, F, et al.
Publicado: (2016)

The deubiquitinase (DUB) USP13 promotes Mcl-1 stabilisation in cervical cancer
por: Morgan, Ethan L., et al.
Publicado: (2021)

Deubiquitinase USP13 dictates MCL1 stability and sensitivity to BH3 mimetic inhibitors
por: Zhang, Shengzhe, et al.
Publicado: (2018)

Targeting deubiquitinase USP28 for cancer therapy
por: Wang, Xiaofang, et al.
Publicado: (2018)

Deubiquitinase USP9X regulates the invasion of prostate cancer cells by regulating the ERK pathway and mitochondrial dynamics
por: Zhang, Jinsong, et al.
Publicado: (2019)

Deubiquitinase USP35 stabilizes BRPF1 to activate mevalonate (MVA) metabolism during prostate tumorigenesis
por: Lin, Guowen, et al.
Publicado: (2022)

Systemic Alterations of Wnt Inhibitors in Patients with Prostate Cancer and Bone Metastases
por: Aufderklamm, Stefan, et al.
Publicado: (2018)

Inhibition of the deubiquitinase USP10 induces degradation of SYK
por: Yang, Jing, et al.
Publicado: (2020)

Intratumoral Heterogeneity Determines the Expression of mTOR-pathway Proteins in Prostate Cancer
por: Russo, Giorgio Ivan, et al.
Publicado: (2019)

Diabetes and the Prostate: Elevated Fasting Glucose, Insulin Resistance and Higher Levels of Adrenal Steroids in Prostate Cancer
por: Lutz, Stefan Zoltán, et al.
Publicado: (2022)

Assessment of a new point-of-care system for detection of prostate specific antigen
por: Rausch, Steffen, et al.
Publicado: (2016)

The deubiquitinase USP11 promotes ovarian cancer chemoresistance by stabilizing BIP
por: Zhu, Xiaolin, et al.
Publicado: (2021)

Micro-Ultrasound: a way to bring imaging for prostate cancer back to urology
por: Harland, Niklas, et al.
Publicado: (2021)

Circulating and Disseminated Tumor Cells in the Management of Advanced Prostate Cancer
por: Kruck, Stephan, et al.
Publicado: (2012)

USP7 and USP47 deubiquitinases regulate NLRP3 inflammasome activation
por: Palazón‐Riquelme, Pablo, et al.
Publicado: (2018)

Deubiquitinase USP19 modulates apoptotic calcium release and endoplasmic reticulum stress by deubiquitinating BAG6 in triple negative breast cancer
por: Zhang, Xiaoqiang, et al.
Publicado: (2023)

The Akt-inhibitor Erufosine induces apoptotic cell death in prostate cancer cells and increases the short term effects of ionizing radiation
por: Rudner, Justine, et al.
Publicado: (2010)

Oncological validation of bone turnover markers c-terminal telopeptide of type I collagen (1CTP) and peptides n-terminal propeptide of type I procollagen (P1NP) in patients with prostate cancer and bone metastases
por: Aufderklamm, Stefan, et al.
Publicado: (2021)

Deubiquitinase USP20 promotes breast cancer metastasis by stabilizing SNAI2
por: Li, Wenyang, et al.
Publicado: (2020)

Deubiquitinase USP35 modulates ferroptosis in lung cancer via targeting ferroportin
por: Tang, Zheng, et al.
Publicado: (2021)

Behavioral phenotyping of mice lacking the deubiquitinase USP2
por: Srikanta, Shashank Bangalore, et al.
Publicado: (2021)

Role of Multiparametric Magnetic Resonance Imaging in Predicting Pathologic Outcomes in Prostate Cancer
por: Harland, Niklas, et al.
Publicado: (2021)

USP48/USP31 Is a Nuclear Deubiquitinase that Potently Regulates Synapse Remodeling
por: Ma, Qi, et al.
Publicado: (2023)

Circulating tumor cells and their role in prostate cancer
por: Maas, Moritz, et al.
Publicado: (2019)

Deubiquitinase USP7-mediated MCL-1 up-regulation enhances Arsenic and Benzo(a)pyrene co-exposure-induced Cancer Stem Cell-like property and Tumorigenesis
por: Yang, Ping, et al.
Publicado: (2020)

Bone Health Issues in Patients with Prostate Cancer: An Evidence-Based Review
por: Walz, Simon, et al.
Publicado: (2020)

The deubiquitinase USP9X regulates FBW7 stability and suppresses colorectal cancer
por: Khan, Omar M., et al.
Publicado: (2018)

The deubiquitinase USP54 is overexpressed in colorectal cancer stem cells and promotes intestinal tumorigenesis
por: Fraile, Julia M., et al.
Publicado: (2016)

The deubiquitinase USP22 regulates PD-L1 degradation in human cancer cells
por: Wang, Yu, et al.
Publicado: (2020)

USP21 deubiquitinase elevates macropinocytosis to enable oncogenic KRAS bypass in pancreatic cancer
por: Hou, Pingping, et al.
Publicado: (2021)

The deubiquitinase USP8 regulates ovarian cancer cell response to cisplatin by suppressing apoptosis
por: Corno, Cristina, et al.
Publicado: (2022)

The deubiquitinase USP10 protects pancreatic cancer cells from endoplasmic reticulum stress
por: Bhattacharya, Udayan, et al.
Publicado: (2022)

Human Prostate Cancer Is Characterized by an Increase in Urea Cycle Metabolites
por: Franko, Andras, et al.
Publicado: (2020)

The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma
por: Pérez-Mancera, Pedro A., et al.
Publicado: (2012)

Mice null for the deubiquitinase USP18 spontaneously develop leiomyosarcomas
por: Chinyengetere, Fadzai, et al.
Publicado: (2015)

Mechanism and regulation of the Lys6-selective deubiquitinase USP30
por: Gersch, Malte, et al.
Publicado: (2017)

The Regulations of Deubiquitinase USP15 and Its Pathophysiological Mechanisms in Diseases
por: Chou, Chon-Kit, et al.
Publicado: (2017)

The deubiquitinase USP11 is a versatile and conserved regulator of autophagy
por: Basic, Mila, et al.
Publicado: (2021)

Regulation of Bax-dependent apoptosis by mitochondrial deubiquitinase USP30
por: Yan, Ding, et al.
Publicado: (2021)

Stabilization of PIM Kinases in Hypoxia Is Mediated by the Deubiquitinase USP28
por: Toth, Rachel K., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ap083shgcviru3r1idiuvjhjnm