Interaction between Human Papillomavirus-Encoded E6 Protein and AurB Induces Cell Immortalization and Proliferation—A Potential Target of Intervention

SIMPLE SUMMARY: This study identified that Aurora kinase B (AurB), a cellular protein that is upregulated in human cancers, is a bona fide interacting partner of HPVE6. HPVE6 complexes with AurB at the C-terminus end of E6, upstream of the E6-PBM. The AurB-E6 complex forms predominantly in the nucle...

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Detalles Bibliográficos
Autores principales: Boon, Siaw Shi, Lee, Yin Ching, Yip, Ka Lai, Luk, Ho Yin, Xiao, Chuanyun, Yim, Man Kin, Chen, Zigui, Chan, Paul Kay Sheung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10177266/
https://www.ncbi.nlm.nih.gov/pubmed/37173932
http://dx.doi.org/10.3390/cancers15092465

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10177266/
https://www.ncbi.nlm.nih.gov/pubmed/37173932
http://dx.doi.org/10.3390/cancers15092465

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