Directed Evolution of Seneca Valley Virus in Tumorsphere and Monolayer Cell Cultures of a Small-Cell Lung Cancer Model

SIMPLE SUMMARY: Serial passaging of oncolytic viruses in a new host system can increase their infectivity and anti-cancer efficacy by the directed evolution of naturally occurring variants. RNA viruses have a high nucleotide substitution and proof-reading error rate due to the low fidelity of viral...

Descripción completa

Detalles Bibliográficos
Autores principales: Waqqar, Shakeel, Lee, Kai, Lawley, Blair, Bilton, Timothy, Quiñones-Mateu, Miguel E., Bostina, Mihnea, Burga, Laura N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10177334/
https://www.ncbi.nlm.nih.gov/pubmed/37174006
http://dx.doi.org/10.3390/cancers15092541

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10177334/
https://www.ncbi.nlm.nih.gov/pubmed/37174006
http://dx.doi.org/10.3390/cancers15092541

Ejemplares similares