4-[(5-Methyl-1H-pyrazol-3-yl)amino]-2H-phenyl-1-phthalazinone Inhibits MCPyV T Antigen Expression in Merkel Cell Carcinoma Independent of Aurora Kinase A

SIMPLE SUMMARY: Treatment of Merkel cell carcinoma—a deadly skin cancer frequently caused by the Merkel cell polyomavirus—still poses challenges. Since the tumor cells depend on expression of viral oncogenes—named T antigens—targeting the expression of these T antigens appears as a potential therape...

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Detalles Bibliográficos
Autores principales: Houben, Roland, Alimova, Pamela, Sarma, Bhavishya, Hesbacher, Sonja, Schulte, Carolin, Sarosi, Eva-Maria, Adam, Christian, Kervarrec, Thibault, Schrama, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10177447/
https://www.ncbi.nlm.nih.gov/pubmed/37174007
http://dx.doi.org/10.3390/cancers15092542

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10177447/
https://www.ncbi.nlm.nih.gov/pubmed/37174007
http://dx.doi.org/10.3390/cancers15092542

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