Histidine Enhances the Anticancer Effect of Gemcitabine against Pancreatic Cancer via Disruption of Amino Acid Homeostasis and Oxidant—Antioxidant Balance

SIMPLE SUMMARY: Amino acid metabolism is aberrantly altered in pancreatic cancer (PC). Evidence suggests that circulating histidine (His) levels are low in PC. However, the role of His in modulating the progression of PC remains unknown. We determined the role of His in altering the therapeutic effe...

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Detalles Bibliográficos
Autores principales: Kumar, Narendra, Rachagani, Satyanarayana, Natarajan, Gopalakrishnan, Crook, Alexandra, Gopal, Thiyagarajan, Rajamanickam, Vinothkumar, Kaushal, Jyoti B., Nagabhishek, Sirpu N., Powers, Robert, Batra, Surinder K., Saraswathi, Viswanathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10177467/
https://www.ncbi.nlm.nih.gov/pubmed/37174059
http://dx.doi.org/10.3390/cancers15092593

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10177467/
https://www.ncbi.nlm.nih.gov/pubmed/37174059
http://dx.doi.org/10.3390/cancers15092593

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