Cargando…

Histidine Enhances the Anticancer Effect of Gemcitabine against Pancreatic Cancer via Disruption of Amino Acid Homeostasis and Oxidant—Antioxidant Balance

SIMPLE SUMMARY: Amino acid metabolism is aberrantly altered in pancreatic cancer (PC). Evidence suggests that circulating histidine (His) levels are low in PC. However, the role of His in modulating the progression of PC remains unknown. We determined the role of His in altering the therapeutic effe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kumar, Narendra, Rachagani, Satyanarayana, Natarajan, Gopalakrishnan, Crook, Alexandra, Gopal, Thiyagarajan, Rajamanickam, Vinothkumar, Kaushal, Jyoti B., Nagabhishek, Sirpu N., Powers, Robert, Batra, Surinder K., Saraswathi, Viswanathan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10177467/ https://www.ncbi.nlm.nih.gov/pubmed/37174059 http://dx.doi.org/10.3390/cancers15092593

Ejemplares similares

Gut microbiota: a non-target victim of pesticide-induced toxicity
por: Sharma, Tusha, et al.
Publicado: (2023)

Emerging Role of miR-345 and Its Effective Delivery as a Potential Therapeutic Candidate in Pancreatic Cancer and Other Cancers
por: Natesh, Nagabhishek Sirpu, et al.
Publicado: (2021)

Pancreatic cancer associated with obesity and diabetes: an alternative approach for its targeting
por: Pothuraju, Ramesh, et al.
Publicado: (2018)

Ubiquitous Aberration in Cholesterol Metabolism across Pancreatic Ductal Adenocarcinoma
por: Gunda, Venugopal, et al.
Publicado: (2022)

A novel apoptosis-inducing metabolite isolated from marine sponge symbiont Monascus sp. NMK7 attenuates cell proliferation, migration and ROS stress-mediated apoptosis in breast cancer cells
por: Nagabhishek, Sirpu Natesh, et al.
Publicado: (2019)

Correction: Kaushal et al. Repurposing Niclosamide for Targeting Pancreatic Cancer by Inhibiting Hh/Gli Non-Canonical Axis of Gsk3β. Cancers 2021, 13, 3105
por: Kaushal, Jyoti B., et al.
Publicado: (2021)

Repurposing Niclosamide for Targeting Pancreatic Cancer by Inhibiting Hh/Gli Non-Canonical Axis of Gsk3β
por: Kaushal, Jyoti B., et al.
Publicado: (2021)

PD2/Paf1 depletion in pancreatic acinar cells promotes acinar-to-ductal metaplasia
por: Dey, Parama, et al.
Publicado: (2014)

Lauric Acid versus Palmitic Acid: Effects on Adipose Tissue Inflammation, Insulin Resistance, and Non-Alcoholic Fatty Liver Disease in Obesity
por: Saraswathi, Viswanathan, et al.
Publicado: (2020)

Association of hypercoagulation with severe acute respiratory syndrome coronavirus 2 infection
por: Nuthalapati, Poojith, et al.
Publicado: (2021)

CXCR2 signaling regulates KRAS((G12D))-induced autocrine growth of pancreatic cancer
por: Purohit, Abhilasha, et al.
Publicado: (2016)

Trefoil factor(s) and CA19.9: A promising panel for early detection of pancreatic cancer
por: Jahan, Rahat, et al.
Publicado: (2019)

Novel Pancreatic Cancer Cell Lines Derived from Genetically Engineered Mouse Models of Spontaneous Pancreatic Adenocarcinoma: Applications in Diagnosis and Therapy
por: Torres, María P., et al.
Publicado: (2013)

Membrane proximal ectodomain cleavage of MUC16 occurs in the acidifying Golgi/post-Golgi compartments
por: Das, Srustidhar, et al.
Publicado: (2015)

Mucins, gut microbiota, and postbiotics role in colorectal cancer
por: Pothuraju, Ramesh, et al.
Publicado: (2021)

Myristic Acid Supplementation Aggravates High Fat Diet-Induced Adipose Inflammation and Systemic Insulin Resistance in Mice
por: Saraswathi, Viswanathan, et al.
Publicado: (2022)

Comparative Study of Subcutaneous and Orthotopic Mouse Models of Prostate Cancer: Vascular Perfusion, Vasculature Density, Hypoxic Burden and BB2r-Targeting Efficacy
por: Zhang, Wenting, et al.
Publicado: (2019)

Novel role of O-glycosyltransferases GALNT3 and B3GNT3 in the self-renewal of pancreatic cancer stem cells
por: Barkeer, Srikanth, et al.
Publicado: (2018)

A marine sponge associated fungal metabolite monacolin X suppresses angiogenesis by down regulating VEGFR2 signaling
por: Nagabhishek, Sirpu Natesh, et al.
Publicado: (2019)

Nicotine/Cigarette-smoke Promotes Metastasis of Pancreatic Cancer Through α7nAChR-mediated MUC4 Up-regulation
por: Momi, Navneet, et al.
Publicado: (2012)

Inhibition of hedgehog signaling improves the anti-carcinogenic effects of docetaxel in prostate cancer
por: Mimeault, Murielle, et al.
Publicado: (2015)

Targeting EGF-receptor(s) - STAT1 axis attenuates tumor growth and metastasis through downregulation of MUC4 mucin in human pancreatic cancer
por: Seshacharyulu, Parthasarathy, et al.
Publicado: (2014)

Changes in microRNA (miRNA) expression during pancreatic cancer development and progression in a genetically engineered Kras(G12D);Pdx1-Cre mouse (KC) model
por: Rachagani, Satyanarayana, et al.
Publicado: (2015)

Mechanistic and Functional Shades of Mucins and Associated Glycans in Colon Cancer
por: Pothuraju, Ramesh, et al.
Publicado: (2020)

Carboxyl-terminal domain of MUC16 imparts tumorigenic and metastatic functions through nuclear translocation of JAK2 to pancreatic cancer cells
por: Das, Srustidhar, et al.
Publicado: (2015)

Pathological and functional significance of Semaphorin-5A in pancreatic cancer progression and metastasis
por: Saxena, Sugandha, et al.
Publicado: (2017)

MUC16 contributes to the metastasis of pancreatic ductal adenocarcinoma through focal adhesion mediated signaling mechanism
por: Muniyan, Sakthivel, et al.
Publicado: (2016)

Acinar transformed ductal cells exhibit differential mucin expression in a tamoxifen-induced pancreatic ductal adenocarcinoma mouse model
por: Mallya, Kavita, et al.
Publicado: (2020)

Anticancer Potential of L-Histidine-Capped Silver Nanoparticles against Human Cervical Cancer Cells (SiHA)
por: Mohammed Asik, Rajmohamed, et al.
Publicado: (2021)

Depletion of transmembrane mucin 4 (Muc4) alters intestinal homeostasis in a genetically engineered mouse model of colorectal cancer
por: Pothuraju, Ramesh, et al.
Publicado: (2022)

Triptonide Modulates MAPK Signaling Pathways and Exerts Anticancer Effects via ER Stress-Mediated Apoptosis Induction in Human Osteosarcoma Cells
por: Zheng, Liyun, et al.
Publicado: (2020)

Roles unveiled for membrane-associated mucins at the ocular surface using a Muc4 knockout mouse model
por: Martinez-Carrasco, Rafael, et al.
Publicado: (2023)

Implications of prognosis-associated genes in pancreatic tumor metastasis: lessons from global studies in bioinformatics
por: Kisling, Sophia G., et al.
Publicado: (2021)

In Silico Characterization of Histidine Acid Phytase Sequences
por: Kumar, Vinod, et al.
Publicado: (2012)

Gemcitabine-incorporated polyurethane films for controlled release of an anticancer drug
por: Choi, Seong Hoon, et al.
Publicado: (2019)

Inhibition of glucuronidation in pancreatic cancer improves gemcitabine anticancer activity
por: Fraunhoffer, Nicolas Alejandro, et al.
Publicado: (2022)

Novel HER3/MUC4 oncogenic signaling aggravates the tumorigenic phenotypes of pancreatic cancer cells
por: Lakshmanan, Imayavaramban, et al.
Publicado: (2015)

MUC4 is negatively regulated through the Wnt/β-catenin pathway via the Notch effector Hath1 in colorectal cancer
por: Pai, Priya, et al.
Publicado: (2016)

Afatinib and Temozolomide combination inhibits tumorigenesis by targeting EGFRvIII-cMet signaling in glioblastoma cells
por: Vengoji, Raghupathy, et al.
Publicado: (2019)

Plexin-B3 Regulates Cellular Motility, Invasiveness, and Metastasis in Pancreatic Cancer
por: Saxena, Sugandha, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_c8hojcov6msp0v5er5bo2c55ji