Exploring the Therapeutic Potential of Elastase Inhibition in Age-Related Macular Degeneration in Mouse and Human

Abnormal turnover of the extracellular matrix (ECM) protein elastin has been linked to AMD pathology. Elastin is a critical component of Bruch’s membrane (BrM), an ECM layer that separates the retinal pigment epithelium (RPE) from the underlying choriocapillaris. Reduced integrity of BrM’s elastin l...

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Detalles Bibliográficos
Autores principales: Navneet, Soumya, Brandon, Carlene, Simpson, Kit, Rohrer, Bärbel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10177483/
https://www.ncbi.nlm.nih.gov/pubmed/37174708
http://dx.doi.org/10.3390/cells12091308

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10177483/
https://www.ncbi.nlm.nih.gov/pubmed/37174708
http://dx.doi.org/10.3390/cells12091308

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