An Isoxazoloquinone Derivative Inhibits Tumor Growth by Targeting STAT3 and Triggering Its Ubiquitin-Dependent Degradation

SIMPLE SUMMARY: We designed and synthesized a series of novel naphthoquinone derivatives, of which ZSW has a high activity to inhibit the growth of tumor cells and low toxicity. We determined that ZSW suppresses triple-negative breast cancer cell activity by targeting STAT3 and provides a new compou...

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Detalles Bibliográficos
Autores principales: Xie, Yuanzhu, Zhu, Shuaiwen, Chen, Ling, Liu, Hongdou, Peng, Ting, Ming, Zhengnan, Zou, Zizheng, Hu, Xiyuan, Luo, Wensong, Peng, Kunjian, Nie, Yuan, Luo, Tiao, Ma, Dayou, Liu, Suyou, Luo, Zhiyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10177496/
https://www.ncbi.nlm.nih.gov/pubmed/37173892
http://dx.doi.org/10.3390/cancers15092424

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10177496/
https://www.ncbi.nlm.nih.gov/pubmed/37173892
http://dx.doi.org/10.3390/cancers15092424

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