A computationally designed ACE2 decoy has broad efficacy against SARS-CoV-2 omicron variants and related viruses in vitro and in vivo

SARS-CoV-2, especially B.1.1.529/omicron and its sublineages, continues to mutate to evade monoclonal antibodies and antibodies elicited by vaccination. Affinity-enhanced soluble ACE2 (sACE2) is an alternative strategy that works by binding the SARS-CoV-2 S protein, acting as a ‘decoy’ to block the...

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Detalles Bibliográficos
Autores principales: Havranek, Brandon, Lindsey, Graeme Walker, Higuchi, Yusuke, Itoh, Yumi, Suzuki, Tatsuya, Okamoto, Toru, Hoshino, Atsushi, Procko, Erik, Islam, Shahidul M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10177734/
https://www.ncbi.nlm.nih.gov/pubmed/37173421
http://dx.doi.org/10.1038/s42003-023-04860-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10177734/
https://www.ncbi.nlm.nih.gov/pubmed/37173421
http://dx.doi.org/10.1038/s42003-023-04860-9

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