Cargando…

Metabolic Effects of New Glucose Transporter (GLUT-1) and Lactate Dehydrogenase-A (LDH-A) Inhibitors against Chemoresistant Malignant Mesothelioma

Malignant mesothelioma (MM) is a highly aggressive and resistant tumor. The prognostic role of key effectors of glycolytic metabolism in MM prompted our studies on the cytotoxicity of new inhibitors of glucose transporter type 1 (GLUT-1) and lactate dehydrogenase-A (LDH-A) in relation to ATP/NAD(+)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Franczak, Marika A., Krol, Oliwia, Harasim, Gabriela, Jedrzejewska, Agata, Zaffaroni, Nadia, Granchi, Carlotta, Minutolo, Filippo, Avan, Amir, Giovannetti, Elisa, Smolenski, Ryszard T., Peters, Godefridus J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10177874/ https://www.ncbi.nlm.nih.gov/pubmed/37175477 http://dx.doi.org/10.3390/ijms24097771

Ejemplares similares

Lactate dehydrogenase A inhibition by small molecular entities: steps in the right direction
por: El Hassouni, Btissame, et al.
Publicado: (2020)

Correction: Lactate dehydrogenase A inhibition by small molecular entities: steps in the right direction
por: El Hassouni, Btissame, et al.
Publicado: (2021)

Impact of hypoxia on chemoresistance of mesothelioma mediated by the proton-coupled folate transporter, and preclinical activity of new anti-LDH-A compounds
por: Li Petri, Giovanna, et al.
Publicado: (2020)

Target Therapy in Malignant Pleural Mesothelioma: Hope or Mirage?
por: Borea, Federica, et al.
Publicado: (2023)

Three-Dimensional Analysis of the Interactions between hLDH5 and Its Inhibitors
por: Poli, Giulio, et al.
Publicado: (2017)

Macrophage-Derived Adenosine Deaminase 2 Correlates with M2 Macrophage Phenotype in Triple Negative Breast Cancer
por: Kutryb-Zajac, Barbara, et al.
Publicado: (2021)

Synthesis and Biological Evaluation of New Glycoconjugated LDH Inhibitors as Anticancer Agents †
por: D’Andrea, Felicia, et al.
Publicado: (2019)

Changes in Adenosine Deaminase Activity and Endothelial Dysfunction after Mild Coronavirus Disease-2019
por: Jedrzejewska, Agata, et al.
Publicado: (2023)

Synergistic interaction of novel lactate dehydrogenase inhibitors with gemcitabine against pancreatic cancer cells in hypoxia
por: Maftouh, M, et al.
Publicado: (2014)

Phospho-Akt overexpression is prognostic and can be used to tailor the synergistic interaction of Akt inhibitors with gemcitabine in pancreatic cancer
por: Massihnia, Daniela, et al.
Publicado: (2017)

Targeting GLUT1 in acute myeloid leukemia to overcome cytarabine resistance
por: Åbacka, Hannah, et al.
Publicado: (2021)

Cardiac Mitochondria Dysfunction in Dyslipidemic Mice
por: Braczko, Alicja, et al.
Publicado: (2022)

Lactate dehydrogenase-A inhibition induces human glioblastoma multiforme stem cell differentiation and death
por: Daniele, Simona, et al.
Publicado: (2015)

Development and Validation of a Docking-Based Virtual Screening Platform for the Identification of New Lactate Dehydrogenase Inhibitors
por: Granchi, Carlotta, et al.
Publicado: (2015)

Validating lactate dehydrogenase (LDH) as a component of the PLASMIC predictive tool (PLASMIC-LDH)
por: Liam, Christopher Chin Keong, et al.
Publicado: (2023)

Rosiglitazone Ameliorates Cardiac and Skeletal Muscle Dysfunction by Correction of Energetics in Huntington’s Disease
por: Tomczyk, Marta, et al.
Publicado: (2022)

Identification of LDH-A as a therapeutic target for cancer cell killing via (i) p53/NAD(H)-dependent and (ii) p53-independent pathways
por: Allison, S J, et al.
Publicado: (2014)

Enhanced Muscle Strength in Dyslipidemic Mice and Its Relation to Increased Capacity for Fatty Acid Oxidation
por: Tomczyk, Marta, et al.
Publicado: (2021)

Fungal mycobiome-mediated immune response: a non-negligible promoter in pancreatic oncogenesis and chemoresistance
por: Jiang, Yaling, et al.
Publicado: (2023)

SF3B1 modulators affect key genes in metastasis and drug influx: a new approach to fight pancreatic cancer chemoresistance
por: Randazzo, Ornella, et al.
Publicado: (2021)

Role of Akt signaling in resistance to DNA-targeted therapy
por: Avan, Abolfazl, et al.
Publicado: (2016)

CoCl(2)-Mimicked Endothelial Cell Hypoxia Induces Nucleotide Depletion and Functional Impairment That Is Reversed by Nucleotide Precursors
por: Kutryb-Zajac, Barbara, et al.
Publicado: (2022)

Importance of lactate dehydrogenase (LDH) and monocarboxylate transporters (MCTs) in cancer cells
por: Hatami, Hamed, et al.
Publicado: (2022)

P050: Reed-Sternberg cells accelerate glycolytic and mitochondrial metabolism of tumor microenvironment cells
por: Kurlapski, Michał, et al.
Publicado: (2022)

Zoledronic acid overcomes chemoresistance and immunosuppression of malignant mesothelioma
por: Salaroglio, Iris Chiara, et al.
Publicado: (2014)

TGFα Promotes Chemoresistance of Malignant Pleural Mesothelioma
por: Staumont, Bernard, et al.
Publicado: (2020)

Heterogeneous RNA editing and influence of ADAR2 on mesothelioma chemoresistance and the tumor microenvironment
por: Hariharan, Ananya, et al.
Publicado: (2022)

Diagnostic performance of lactate dehydrogenase (LDH) isoenzymes levels for the severity of COVID-19
por: Ergenc, Ilkay, et al.
Publicado: (2023)

The lactate dehydrogenase (LDH) isoenzyme spectrum enables optimally controlling T cell glycolysis and differentiation
por: Chen, Xuyong, et al.
Publicado: (2023)

Utility of the Ratio between Lactate Dehydrogenase (LDH) Activity and Total Nucleated Cell Counts in Effusions (LDH/TNCC Ratio) for the Diagnosis of Feline Infectious Peritonitis (FIP)
por: Romanelli, Pierpaolo, et al.
Publicado: (2022)

Osteopontin, GLUT1 and Ki‐67 expression in malignant peritoneal mesothelioma: prognostic implications
por: Liu, Yingying, et al.
Publicado: (2021)

Down-Regulation of miR-7 in Gastric Cancer Is Associated With Elevated LDH-A Expression and Chemoresistance to Cisplatin
por: Jin, Hui-Fang, et al.
Publicado: (2020)

Elevated Lactate Dehydrogenase (LDH) level as an independent risk factor for the severity and mortality of COVID-19
por: Li, Chang, et al.
Publicado: (2020)

Can lactate dehydrogenase (LDH) be used as a marker of severity of pneumonia in patients with renal transplant?
por: Luna, Carlos M., et al.
Publicado: (2020)

Correlation of Serum IL-17, VEGF, and Lactate Dehydrogenase (LDH) Levels with Prognosis of Gastric Cancer
por: Rao, Shumei, et al.
Publicado: (2022)

Evaluation of lactate dehydrogenase (LDH) in predicting the severity of lung involvement and pneumomediastinum in hospitalized COVID-19
por: Eid, Hind, et al.
Publicado: (2022)

Splicing modulation as novel therapeutic strategy against diffuse malignant peritoneal mesothelioma
por: Sciarrillo, Rocco, et al.
Publicado: (2018)

Differences in Extracellular NAD(+) and NMN Metabolism on the Surface of Vascular Endothelial Cells
por: Jablonska, Patrycja, et al.
Publicado: (2022)

Effects and Mechanism of Atmospheric-Pressure Dielectric Barrier Discharge Cold Plasma on Lactate Dehydrogenase (LDH) Enzyme
por: Zhang, Hao, et al.
Publicado: (2015)

Reversible Monoacylglycerol Lipase Inhibitors: Discovery of a New Class of Benzylpiperidine Derivatives
por: Bononi, Giulia, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_2uodjb8qgnhq86lpdf1gl8mgsm