Midbrain dopamine oxidation links ubiquitination of glutathione peroxidase 4 to ferroptosis of dopaminergic neurons

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Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the gradual loss of midbrain dopaminergic neurons in association with aggregation of α-synuclein. Oxidative damage has been widely implicated in this disease, though the mechanisms involved remain elusive. Here, we demonstrate...

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Detalles Bibliográficos
Autores principales: Sun, Jie, Lin, Xiao-Min, Lu, Dan-Hua, Wang, Meng, Li, Kun, Li, Sheng-Rong, Li, Zheng-Qiu, Zhu, Cheng-Jun, Zhang, Zhi-Min, Yan, Chang-Yu, Pan, Ming-Hai, Gong, Hai-Biao, Feng, Jing-Cheng, Cao, Yun-Feng, Huang, Feng, Sun, Wan-Yang, Kurihara, Hiroshi, Li, Yi-Fang, Duan, Wen-Jun, Jiao, Gen-Long, Zhang, Li, He, Rong-Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10178840/
https://www.ncbi.nlm.nih.gov/pubmed/37183824
http://dx.doi.org/10.1172/JCI165228

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10178840/
https://www.ncbi.nlm.nih.gov/pubmed/37183824
http://dx.doi.org/10.1172/JCI165228

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