Cargando…

Tau Lysine Pseudomethylation Regulates Microtubule Binding and Enhances Prion-like Tau Aggregation

Alzheimer’s disease (AD) and frontotemporal dementia (FTD) can be classified as tauopathies, which are a group of neurodegenerative diseases that develop toxic tau aggregates in specific brain regions. These pathological tau inclusions are altered by various post-translational modifications (PTMs) t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xia, Yuxing, Bell, Brach M., Giasson, Benoit I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10179186/ https://www.ncbi.nlm.nih.gov/pubmed/37175990 http://dx.doi.org/10.3390/ijms24098286

Ejemplares similares

Tau mutation S356T in the three repeat isoform leads to microtubule dysfunction and promotes prion-like seeded aggregation
por: Xia, Yuxing, et al.
Publicado: (2023)

Tau K321/K353 pseudoacetylation within KXGS motifs regulates tau–microtubule interactions and inhibits aggregation
por: Xia, Yuxing, et al.
Publicado: (2021)

Reassessment of Neuronal Tau Distribution in Adult Human Brain and Implications for Tau Pathobiology
por: Paterno, Giavanna, et al.
Publicado: (2022)

Tau Ser208 phosphorylation promotes aggregation and reveals neuropathologic diversity in Alzheimer’s disease and other tauopathies
por: Xia, Yuxing, et al.
Publicado: (2020)

“Don’t Phos Over Tau”: recent developments in clinical biomarkers and therapies targeting tau phosphorylation in Alzheimer’s disease and other tauopathies
por: Xia, Yuxing, et al.
Publicado: (2021)

Novel monoclonal antibodies targeting the microtubule-binding domain of human tau
por: Croft, Cara L., et al.
Publicado: (2018)

Tau antibody 77G7 targeting microtubule binding domain suppresses proteopathic tau to seed tau aggregation
por: Li, Longfei, et al.
Publicado: (2022)

Aggregation of Microtubule Binding Repeats of Tau Protein is Promoted by Cu(2+)
por: Ahmadi, Soha, et al.
Publicado: (2019)

Pathogenic tau recruits wild-type tau into brain inclusions and induces gut degeneration in transgenic SPAM mice
por: Xia, Yuxing, et al.
Publicado: (2022)

Conserved Lysine Acetylation within the Microtubule-Binding Domain Regulates MAP2/Tau Family Members
por: Hwang, Andrew W., et al.
Publicado: (2016)

Motifs in the tau protein that control binding to microtubules and aggregation determine pathological effects
por: Lathuilière, Aurélien, et al.
Publicado: (2017)

Microtubule-binding core of the tau protein
por: El Mammeri, Nadia, et al.
Publicado: (2022)

Novel Conformation-Dependent Tau Antibodies Are Modulated by Adjacent Phosphorylation Sites
por: Paterno, Giavanna, et al.
Publicado: (2023)

Phosphorylation of the overlooked tyrosine 310 regulates the structure, aggregation, and microtubule- and lipid-binding properties of Tau
por: Ait-Bouziad, Nadine, et al.
Publicado: (2020)

Tau binding protein CAPON induces tau aggregation and neurodegeneration
por: Hashimoto, Shoko, et al.
Publicado: (2019)

Heterotypic seeding of Tau fibrillization by pre-aggregated Abeta provides potent seeds for prion-like seeding and propagation of Tau-pathology in vivo
por: Vasconcelos, Bruno, et al.
Publicado: (2016)

The prion-like transmission of tau oligomers via exosomes
por: Jackson, Noel A., et al.
Publicado: (2022)

Partial mimicry of the microtubule binding of tau by its membrane binding
por: MacAinsh, Matthew, et al.
Publicado: (2023)

Author Correction: Tau binding protein CAPON induces tau aggregation and neurodegeneration
por: Hashimoto, Shoko, et al.
Publicado: (2019)

Conformation-Specific Association of Prion Protein Amyloid Aggregates with Tau Protein Monomers
por: Ziaunys, Mantas, et al.
Publicado: (2023)

Differential induction of mutant SOD1 misfolding and aggregation by tau and α-synuclein pathology
por: Pace, Michael C., et al.
Publicado: (2018)

Tau proteins: the molecular structure and mode of binding on microtubules
Publicado: (1988)

Suppressing Tau Aggregation and Toxicity by an Anti-Aggregant Tau Fragment
por: Pir, Ghulam Jeelani, et al.
Publicado: (2018)

FRET-based Tau seeding assay does not represent prion-like templated assembly of Tau filaments
por: Kaniyappan, Senthilvelrajan, et al.
Publicado: (2020)

The organization of microtubules and Tau in oligodendrocytes: Tau pathology in damaged oligodendrocytes
por: Torii, Tomohiro, et al.
Publicado: (2022)

Aggregation, Transmission, and Toxicity of the Microtubule-Associated Protein Tau: A Complex Comprehension
por: Hu, Jiaxin, et al.
Publicado: (2023)

Modified heptapeptide from tau binds both tubulin and microtubules
por: Li, Jingrui, et al.
Publicado: (2020)

Microtubules Gate Tau Condensation to Spatially Regulate Microtubule Functions
por: Tan, Ruensern, et al.
Publicado: (2019)

T-Tau and P-Tau in Brain and Blood from Natural and Experimental Prion Diseases
por: Rubenstein, Richard, et al.
Publicado: (2015)

Human tau pathology transmits glial tau aggregates in the absence of neuronal tau
por: Narasimhan, Sneha, et al.
Publicado: (2019)

Prion-Like Behavior and Tau-dependent Cytotoxicity of Pyroglutamylated β-Amyloid
por: Nussbaum, Justin M., et al.
Publicado: (2012)

What is the evidence that tau pathology spreads through prion-like propagation?
por: Mudher, Amrit, et al.
Publicado: (2017)

Targeting Prion-like Cis Phosphorylated Tau Pathology in Neurodegenerative Diseases
por: Albayram, Onder, et al.
Publicado: (2018)

Specific binding of Hsp27 and phosphorylated Tau mitigates abnormal Tau aggregation-induced pathology
por: Zhang, Shengnan, et al.
Publicado: (2022)

Propagation of Tau aggregates
por: Goedert, Michel, et al.
Publicado: (2017)

EGCG impedes human Tau aggregation and interacts with Tau
por: Sonawane, Shweta Kishor, et al.
Publicado: (2020)

Differential Effects of the Six Human TAU Isoforms: Somatic Retention of 2N-TAU and Increased Microtubule Number Induced by 4R-TAU
por: Bachmann, Sarah, et al.
Publicado: (2021)

The Prion 2018 round tables (II): Aβ, tau, α-synuclein… are they prions, prion-like proteins, or what?
por: Eraña, Hasier
Publicado: (2019)

Tau, prions and Aβ: the triad of neurodegeneration
por: Reiniger, Lilla, et al.
Publicado: (2010)

Structure of Tau filaments in Prion protein amyloidoses
por: Hallinan, Grace I., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_t7bd3gnkufnbvvh4qurfeteies