MYCN Amplification Is Associated with Reduced Expression of Genes Encoding γ-Secretase Complex and NOTCH Signaling Components in Neuroblastoma

Amplification of the MYCN oncogene is found in ~20% of neuroblastoma (NB) cases and correlates with high-risk disease and poor prognosis. Despite the plethora of studies describing the role of MYCN in NB, the exact molecular mechanisms underlying MYCN’s contribution to high-risk disease are not comp...

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Detalles Bibliográficos
Autores principales: Agarwal, Prasoon, Glowacka, Aleksandra, Mahmoud, Loay, Bazzar, Wesam, Larsson, Lars-Gunnar, Alzrigat, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10179553/
https://www.ncbi.nlm.nih.gov/pubmed/37175848
http://dx.doi.org/10.3390/ijms24098141

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10179553/
https://www.ncbi.nlm.nih.gov/pubmed/37175848
http://dx.doi.org/10.3390/ijms24098141

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