Thiocholine-Mediated One-Pot Peptide Ligation and Desulfurization

Thiol catalysts are essential in native chemical ligation (NCL) to increase the reaction efficiency. In this paper, we report the use of thiocholine in chemical protein synthesis, including NCL-based peptide ligation and metal-free desulfurization. Evaluation of thiocholine peptide thioester in term...

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Detalles Bibliográficos
Autores principales: Suzuki, Sae, Nakajima, Yuya, Kamo, Naoki, Osakabe, Akihisa, Okamoto, Akimitsu, Hayashi, Gosuke, Murakami, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10179797/
https://www.ncbi.nlm.nih.gov/pubmed/37175065
http://dx.doi.org/10.3390/molecules28093655

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10179797/
https://www.ncbi.nlm.nih.gov/pubmed/37175065
http://dx.doi.org/10.3390/molecules28093655

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