Synthesis and Antitumor Evaluation of Biotin-SN38-Valproic Acid Conjugates

Despite the strong anticancer activity of SN38 (7-ethyl-10-hydroxy-camptothecin), the severe side effects and loss of anticancer activity caused by the lack of selectivity to cancer cells and hydrolysis of ring E prevent its clinical application. To address the issue, herein a multifunctional SN38 d...

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Detalles Bibliográficos
Autores principales: Dai, Yi, Zhang, Yang, Ye, Tianxiang, Chen, Yue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10179906/
https://www.ncbi.nlm.nih.gov/pubmed/37175346
http://dx.doi.org/10.3390/molecules28093936

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10179906/
https://www.ncbi.nlm.nih.gov/pubmed/37175346
http://dx.doi.org/10.3390/molecules28093936

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