Cytotoxic Activity, Topoisomerase I Inhibition and In Silico Studies of New Sesquiterpene-aryl Ester Derivatives of (-) Drimenol

In this study, we aimed to evaluate two sets of sesquiterpene-aryl derivatives linked by an ester bond, their cytotoxic activities, and their capacity to activate caspases 3/7 and inhibit human topoisomerase I (TOP1). A total of 13 compounds were synthesized from the natural sesquiterpene (-)-drimen...

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Detalles Bibliográficos
Autores principales: Araque, Ileana, Ramírez, Javiera, Vergara, Rut, Mella, Jaime, Aránguiz, Pablo, Espinoza, Luis, Vera, Waleska, Montenegro, Iván, Salas, Cristian O., Villena, Joan, Cuellar, Mauricio A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10179937/
https://www.ncbi.nlm.nih.gov/pubmed/37175368
http://dx.doi.org/10.3390/molecules28093959

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10179937/
https://www.ncbi.nlm.nih.gov/pubmed/37175368
http://dx.doi.org/10.3390/molecules28093959

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