Cargando…

New Hybrid Tetrahydropyrrolo[3,2,1-ij]quinolin-1-ylidene-2-thioxothiazolidin-4-ones as New Inhibitors of Factor Xa and Factor XIa: Design, Synthesis, and In Silico and Experimental Evaluation

Despite extensive research in the field of thrombotic diseases, the prevention of blood clots remains an important area of study. Therefore, the development of new anticoagulant drugs with better therapeutic profiles and fewer side effects to combat thrombus formation is still needed. Herein, we rep...

Descripción completa

Detalles Bibliográficos
Autores principales:	Novichikhina, Nadezhda P., Shestakov, Alexander S., Medvedeva, Svetlana M., Lagutina, Anna M., Krysin, Mikhail Yu., Podoplelova, Nadezhda A., Panteleev, Mikhail A., Ilin, Ivan S., Sulimov, Alexey V., Tashchilova, Anna S., Sulimov, Vladimir B., Geronikaki, Athina, Shikhaliev, Khidmet S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10179972/ https://www.ncbi.nlm.nih.gov/pubmed/37175261 http://dx.doi.org/10.3390/molecules28093851

Ejemplares similares

Synthesis, Docking, and In Vitro Anticoagulant Activity Assay of Hybrid Derivatives of Pyrrolo[3,2,1-ij]Quinolin-2(1H)-one as New Inhibitors of Factor Xa and Factor XIa
por: Novichikhina, Nadezhda, et al.
Publicado: (2020)

New Blood Coagulation Factor XIIa Inhibitors: Molecular Modeling, Synthesis, and Experimental Confirmation
por: Tashchilova, Anna, et al.
Publicado: (2022)

New Chemicals Suppressing SARS-CoV-2 Replication in Cell Culture
por: Sulimov, Alexey, et al.
Publicado: (2022)

Supercomputer Search for the New Inhibitors of the Coagulation Factor XIIa
por: Sulimov, A. V., et al.
Publicado: (2022)

New Aspects of the Reaction of Thioacetamide and N-Substituted Maleimides
por: Aseeva, Yulia V., et al.
Publicado: (2022)

Application of Molecular Modeling to Development of New Factor Xa Inhibitors
por: Sulimov, Vladimir B., et al.
Publicado: (2015)

A New Synthetic Route to Polyhydrogenated Pyrrolo[3,4-b]pyrroles by the Domino Reaction of 3-Bromopyrrole-2,5-Diones with Aminocrotonic Acid Esters
por: Shikhaliev, Khidmet, et al.
Publicado: (2017)

6-Hydroxy-1,2-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
por: Rybakov, Victor B., et al.
Publicado: (2013)

A novel synthetic approach to hydroimidazo[1,5-b]pyridazines by the recyclization of itaconimides and HPLC–HRMS monitoring of the reaction pathway
por: Vandyshev, Dmitry Yu, et al.
Publicado: (2017)

Novel 2,3-Dihydro-1H-pyrrolo[3,2,1-ij]quinazolin-1-ones: Synthesis and Biological Evaluation
por: Mphahlele, Malose J., et al.
Publicado: (2016)

Platelet Surface-Associated Activation and Secretion-Mediated Inhibition of Coagulation Factor XII
por: Zakharova, Natalia V., et al.
Publicado: (2015)

Synthesis, Biological Evaluation and Molecular Docking Studies of 5-Indolylmethylen-4-oxo-2-thioxothiazolidine Derivatives
por: Horishny, Volodymyr, et al.
Publicado: (2022)

Supercomputing, Docking and Quantum Mechanics in Quest for Inhibitors of Papain-like Protease of SARS-CoV-2
por: Sulimov, A. V., et al.
Publicado: (2021)

A Multifield Study on Dimethyl Acetylenedicarboxylate: A Reagent Able to Build a New Cycle on Diaminoimidazoles
por: Vandyshev, Dmitrii Yu., et al.
Publicado: (2022)

6-Ethoxycarbonyl-5,7-dihydroxy-2,3-dihydro-1H-pyrido[3,2,1-ij]quinolinium tribromide
por: Rybakov, Victor B., et al.
Publicado: (2012)

Regioselective Pd-catalyzed direct C1- and C2-arylations of lilolidine for the access to 5,6-dihydropyrrolo[3,2,1-ij]quinoline derivatives
por: Huang, Hai-Yun, et al.
Publicado: (2019)

Circulating Contact-Pathway-Activating Microparticles Together with Factors IXa and XIa Induce Spontaneous Clotting in Plasma of Hematology and Cardiologic Patients
por: Lipets, Elena, et al.
Publicado: (2014)

Recyclization of Maleimides by Binucleophiles as a General Approach for Building Hydrogenated Heterocyclic Systems
por: Vandyshev, Dmitriy Yu., et al.
Publicado: (2022)

Synthesis of 4,5-Dihydro-1H-[1,2]dithiolo[3,4-c]quinoline-1-thione Derivatives and Their Application as Protein Kinase Inhibitors
por: Medvedeva, Svetlana M., et al.
Publicado: (2022)

3-Amino-5-(indol-3-yl)methylene-4-oxo-2-thioxothiazolidine Derivatives as Antimicrobial Agents: Synthesis, Computational and Biological Evaluation
por: Horishny, Volodymyr, et al.
Publicado: (2020)

Methyl 4-methyl-2-oxo-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinoline-6-carboxylate
por: Zhuravleva, Yulia A., et al.
Publicado: (2009)

Crystal structure and DFT study of 8-hydroxy-1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinoline-9-carbaldehyde
por: Faizi, Md. Serajul Haque, et al.
Publicado: (2017)

5-(1H-Indol-3-ylmethylene)-4-oxo-2-thioxothiazolidin-3-yl)alkancarboxylic Acids as Antimicrobial Agents: Synthesis, Biological Evaluation, and Molecular Docking Studies
por: Horishny, Volodymyr, et al.
Publicado: (2020)

N-Derivatives of (Z)-Methyl 3-(4-Oxo-2-thioxothiazolidin-5-ylidene)methyl)-1H-indole-2-carboxylates as Antimicrobial Agents—In Silico and In Vitro Evaluation
por: Petrou, Anthi, et al.
Publicado: (2023)

Comparative Thrombin Generation in Animal Plasma: Sensitivity to Human Factor XIa and Tissue Factor
por: Liang, Yideng, et al.
Publicado: (2023)

N-Aryl-7-hydroxy-5-oxo-2,3-dihydro-1H,5H-pyrido-[3,2,1-ij]quinoline-6-carboxamides. The Synthesis and Effects on Urinary Output
por: Ukrainets, Igor V., et al.
Publicado: (2018)

Decision making in xia2
por: Winter, Graeme, et al.
Publicado: (2013)

In Memorium of Dr. Bing Xia
por: Qian, Jiaming, et al.
Publicado: (2015)

Thrombogenic potential of picomolar coagulation factor XIa is mediated by thrombin wave propagation
por: Parunov, Leonid A., et al.
Publicado: (2023)

Novel SLFN14 mutation associated with macrothrombocytopenia in a patient with severe haemorrhagic syndrome
por: Polokhov, Dmitrii, et al.
Publicado: (2023)

Asymmetrical Forces Dictate the Distribution and Morphology of Platelets in Blood Clots
por: Kovalenko, Tatiana A., et al.
Publicado: (2021)

(S)-1-[(S)-4-Benzyl-2-thioxothiazolidin-3-yl]-3-hydroxybutan-1-one
por: Yang, Jian-hong, et al.
Publicado: (2007)

Fabrication and Characterization of Thin Metal Films Deposited by Electroless Plating with Organic Additives for Electrical Circuits Applications
por: Buylov, Nikita S., et al.
Publicado: (2023)

Quantum-Chemical Quasi-Docking for Molecular Dynamics Calculations
por: Sulimov, Alexey, et al.
Publicado: (2022)

Xia-Gibbs Syndrome: A Review of Literature
por: Goyal, Chanan, et al.
Publicado: (2020)

Synthesis and Structural Determination of Novel 5-Arylidene-3-N(2-alkyloxyaryl)-2-thioxothiazolidin-4-ones
por: Toubal, Khaled, et al.
Publicado: (2012)

8-{(E)-[(4-Chlorophenyl)imino]methyl}-1,1,7,7-tetramethyl-1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinolin-9-ol
por: Kantar, Esen Nur, et al.
Publicado: (2013)

Crystal structure of (E)-9-({[4-(diethylamino)phenyl]imino}methyl)-2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinolin-8-ol
por: Faizi, Md. Serajul Haque, et al.
Publicado: (2017)

IJS: An Intelligent Junction Selection Based Routing Protocol for VANET to Support ITS Services
por: Bhoi, Sourav Kumar, et al.
Publicado: (2014)

AHDC1 missense mutations in Xia-Gibbs syndrome
por: Khayat, Michael M., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_sj6nq9rtpd3e6ce7dc0r8p3f3m