In Silico and In Vitro Assessment of Carbonyl Reductase 1 Inhibition Using ASP9521—A Potent Aldo-Keto Reductase 1C3 Inhibitor with the Potential to Support Anticancer Therapy Using Anthracycline Antibiotics

Anthracycline antibiotics (ANT) are among the most widely used anticancer drugs. Unfortunately, their use is limited due to the development of drug resistance and cardiotoxicity. ANT metabolism, performed mainly by two enzymes—aldo-keto reductase 1C3 (AKR1C3) and carbonyl reductase 1 (CBR1)—is one o...

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Detalles Bibliográficos
Autores principales: Jamrozik, Marek, Piska, Kamil, Bucki, Adam, Koczurkiewicz-Adamczyk, Paulina, Sapa, Michał, Władyka, Benedykt, Pękala, Elżbieta, Kołaczkowski, Marcin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10180078/
https://www.ncbi.nlm.nih.gov/pubmed/37175180
http://dx.doi.org/10.3390/molecules28093767

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10180078/
https://www.ncbi.nlm.nih.gov/pubmed/37175180
http://dx.doi.org/10.3390/molecules28093767

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