Cargando…

Novel Pyrimidine Derivatives as Antioxidant and Anticancer Agents: Design, Synthesis and Molecular Modeling Studies

The heterocyclic ring system of pyrido [2,3-d]pyrimidines is a privileged scaffold in medicinal chemistry, possessing several biological activities. The synthesis of the pyrimidine derivatives was performed via the condensation of a suitable α,β-unsaturated ketone with 4-amino-6-hydroxy-2-mercaptopy...

Descripción completa

Detalles Bibliográficos
Autores principales:	Myriagkou, Malama, Papakonstantinou, Evangelia, Deligiannidou, Georgia-Eirini, Patsilinakos, Alexandros, Kontogiorgis, Christos, Pontiki, Eleni
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10180197/ https://www.ncbi.nlm.nih.gov/pubmed/37175322 http://dx.doi.org/10.3390/molecules28093913

Ejemplares similares

Synthesis, Bioactivity, Pharmacokinetic and Biomimetic Properties of Multi-Substituted Coumarin Derivatives
por: Katopodi, Annita, et al.
Publicado: (2021)

Novel Cinnamic Acid Derivatives as Antioxidant and Anticancer Agents: Design, Synthesis and Modeling Studies
por: Pontiki, Eleni, et al.
Publicado: (2014)

The Role of Natural Products in Rheumatoid Arthritis: Current Knowledge of Basic In Vitro and In Vivo Research
por: Deligiannidou, Georgia-Eirini, et al.
Publicado: (2021)

Use of Edible, Medicinal, and Aromatic Plants in Various Health Disorders: A Cross-Sectional Evaluation among Inhabitants in the Area of Thrace, North-Eastern Greece
por: Deligiannidou, Georgia-Eirini, et al.
Publicado: (2022)

Unraveling Natural Products’ Role in Osteoarthritis Management—An Overview
por: Deligiannidou, Georgia-Eirini, et al.
Publicado: (2020)

Design, Synthesis and Biological Evaluation of New Pyrimidine Derivatives as Anticancer Agents
por: Madia, Valentina Noemi, et al.
Publicado: (2021)

New Indazol-Pyrimidine-Based Derivatives as Selective Anticancer Agents: Design, Synthesis, and In Silico Studies
por: Al-Tuwaijri, Hanaa M., et al.
Publicado: (2023)

Pteridine-2,4-diamine derivatives as radical scavengers and inhibitors of lipoxygenase that can possess anti-inflammatory properties
por: Pontiki, Eleni, et al.
Publicado: (2015)

Synthesis of Novel Indolyl-Pyrimidine Antiinflammatory, Antioxidant and Antibacterial Agents
por: Panda, S. S., et al.
Publicado: (2008)

2-Arylidene-1-indandiones as Pleiotropic Agents with Antioxidant and Inhibitory Enzymes Activities †
por: Kouzi, Olympia, et al.
Publicado: (2019)

Design, synthesis, molecular modelling, and biological evaluation of novel substituted pyrimidine derivatives as potential anticancer agents for hepatocellular carcinoma
por: Ahmed, Naglaa Mohamed, et al.
Publicado: (2019)

New Oxazolo[5,4-d]pyrimidines as Potential Anticancer Agents: Their Design, Synthesis, and In Vitro Biological Activity Research
por: Sochacka-Ćwikła, Aleksandra, et al.
Publicado: (2022)

Novel Pyrimidine Derivatives as Potential Anticancer Agents: Synthesis, Biological Evaluation and Molecular Docking Study
por: Tylińska, Beata, et al.
Publicado: (2021)

Hybridization of Curcumin Analogues with Cinnamic Acid Derivatives as Multi-Target Agents Against Alzheimer’s Disease Targets
por: Chainoglou, Eirini, et al.
Publicado: (2020)

Multi-Target Cinnamic Acids for Oxidative Stress and Inflammation: Design, Synthesis, Biological Evaluation and Modeling Studies
por: Pontiki, Eleni, et al.
Publicado: (2018)

Synthesis and in vitro assay of hydroxyxanthones as antioxidant and anticancer agents
por: Fatmasari, Nela, et al.
Publicado: (2022)

Synthesis of Spirooxindole-O-Naphthoquinone-Tetrazolo[1,5-a]Pyrimidine Hybrids as Potential Anticancer Agents
por: Wu, Liqiang, et al.
Publicado: (2018)

Pyrimidine containing furanose derivative having antifungal, antioxidant, and anticancer activity
por: Dudhe, Rupesh, et al.
Publicado: (2014)

Design, synthesis, molecular docking and biological evaluation of new carbazole derivatives as anticancer, and antioxidant agents
por: Çapan, İrfan, et al.
Publicado: (2023)

Synthesis and Evaluation of Pyrimidine Steroids as Antiproliferative Agents
por: Cortés-Percino, Alejandra, et al.
Publicado: (2019)

Medicinal chemistry perspective of pyrido[2,3-d]pyrimidines as anticancer agents
por: Kumar, Adarsh, et al.
Publicado: (2023)

Pyrazoles and Pyrazolines as Anti-Inflammatory Agents
por: Mantzanidou, Martha, et al.
Publicado: (2021)

Synthesis of Novel Chalcone-Based Phenothiazine Derivatives as Antioxidant and Anticancer Agents
por: Al Zahrani, Nourah A., et al.
Publicado: (2020)

Synthesis of Certain Pyrimidine Derivatives as Antimicrobial Agents and Anti-Inflammatory Agents
por: Mohamed, Mosaad S., et al.
Publicado: (2010)

Design, synthesis, docking, and anticancer evaluations of new thiazolo[3,2-a] pyrimidines as topoisomerase II inhibitors
por: El-Zoghbi, Mona S., et al.
Publicado: (2023)

Design and synthesis of novel oridonin analogues as potent anticancer agents
por: Shen, Qing-Kun, et al.
Publicado: (2018)

Design and Synthesis of Benzimidazole-Chalcone Derivatives as Potential Anticancer Agents
por: Hsieh, Cheng-Ying, et al.
Publicado: (2019)

Synthesis and Biological Evaluation of Novel Isoxazole-Amide Analogues as Anticancer and Antioxidant Agents
por: Eid, Ahmad M., et al.
Publicado: (2021)

Discovery of N,4-Di(1H-pyrazol-4-yl)pyrimidin-2-amine-Derived CDK2 Inhibitors as Potential Anticancer Agents: Design, Synthesis, and Evaluation
por: Fanta, Biruk Sintayehu, et al.
Publicado: (2023)

Design and Synthesis of New Quinoxaline Derivatives as Anticancer Agents and Apoptotic Inducers
por: El Newahie, Aliya M. S., et al.
Publicado: (2019)

Design, Synthesis and Biological Evaluation of Ciprofloxacin- Peptide Conjugates as Anticancer Agents
por: Esfandiari Mazandaran, Kiana, et al.
Publicado: (2019)

Design and Synthesis of Novel Triazole-based Peptide Analogues as Anticancer Agents
por: Baharloui, Maryam, et al.
Publicado: (2019)

Design, synthesis and evaluation of novel enzalutamide analogues as potential anticancer agents
por: Bhole, Ritesh P., et al.
Publicado: (2021)

Design, Synthesis, and Anticancer Screening for Repurposed Pyrazolo[3,4-d]pyrimidine Derivatives on Four Mammalian Cancer Cell Lines
por: Othman, Eman M., et al.
Publicado: (2021)

Design, synthesis, in vitro anticancer, molecular docking and SAR studies of new series of pyrrolo[2,3-d]pyrimidine derivatives
por: Sroor, Farid M., et al.
Publicado: (2023)

Mediterranean Diet Adherence and Subjective Well-Being in a Sample of Portuguese Adults
por: Andrade, Vanda, et al.
Publicado: (2020)

Bis-pyrimidine acetamides: design, synthesis and biological evaluation
por: Kumar, Sanjiv, et al.
Publicado: (2017)

Exploring the 2′-Hydroxy-Chalcone Framework for the Development of Dual Antioxidant and Soybean Lipoxygenase Inhibitory Agents
por: Kostopoulou, Ioanna, et al.
Publicado: (2021)

Steroidal Pyrimidines and Dihydrotriazines as Novel Classes of Anticancer Agents against Hormone-Dependent Breast Cancer Cells
por: Scherbakov, Alexander M., et al.
Publicado: (2018)

Synthesis and biological evaluation of dehydroabietic acid-pyrimidine hybrids as antitumor agents
por: Huang, Lin, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_nooer0m5mqa7uul3ivdtlfrob3