Structural basis of Janus kinase trans-activation

Janus kinases (JAKs) mediate signal transduction downstream of cytokine receptors. Cytokine-dependent dimerization is conveyed across the cell membrane to drive JAK dimerization, trans-phosphorylation, and activation. Activated JAKs in turn phosphorylate receptor intracellular domains (ICDs), result...

Descripción completa

Detalles Bibliográficos
Autores principales: Caveney, Nathanael A., Saxton, Robert A., Waghray, Deepa, Glassman, Caleb R., Tsutsumi, Naotaka, Hubbard, Stevan R., Christopher Garcia, K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10180219/
https://www.ncbi.nlm.nih.gov/pubmed/36867534
http://dx.doi.org/10.1016/j.celrep.2023.112201

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10180219/
https://www.ncbi.nlm.nih.gov/pubmed/36867534
http://dx.doi.org/10.1016/j.celrep.2023.112201

Ejemplares similares