Semi-Rational Design of L-Isoleucine Dioxygenase Generated Its Activity for Aromatic Amino Acid Hydroxylation

Fe (II)-and 2-ketoglutarate-dependent dioxygenases (Fe (II)/α-KG DOs) have been applied to catalyze hydroxylation of amino acids. However, the Fe (II)/α-KG DOs that have been developed and characterized are not sufficient. L-isoleucine dioxygenase (IDO) is an Fe (II)/α-KG DO that specifically cataly...

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Detalles Bibliográficos
Autores principales: An, Jianhong, Guan, Jiaojiao, Nie, Yao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10180240/
https://www.ncbi.nlm.nih.gov/pubmed/37175159
http://dx.doi.org/10.3390/molecules28093750

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10180240/
https://www.ncbi.nlm.nih.gov/pubmed/37175159
http://dx.doi.org/10.3390/molecules28093750

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