Molecular Basis for the Selectivity of DHA and EPA in Sudlow’s Drug Binding Sites in Human Serum Albumin with the Combined Use of NMR and Docking Calculations

Medium- and long-chain saturated and unsaturated free fatty acids (FFAs) are known to bind to human serum albumin (HSA), the main plasma carrier protein. Atomic-level structural data regarding the binding mode in Sudlow’s sites I (FA7) and II (FA4, FA3) of the polyunsaturated ω-3 fatty acids docosah...

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Detalles Bibliográficos
Autores principales: Alexandri, Eleni, Venianakis, Themistoklis, Primikyri, Alexandra, Papamokos, Georgios, Gerothanassis, Ioannis P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10180286/
https://www.ncbi.nlm.nih.gov/pubmed/37175134
http://dx.doi.org/10.3390/molecules28093724

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10180286/
https://www.ncbi.nlm.nih.gov/pubmed/37175134
http://dx.doi.org/10.3390/molecules28093724

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