Synthesis and Antineoplastic Activity of a Dimer, Spiroindolinone Pyrrolidinecarboxamide

The mutation or function loss of tumour suppressor p53 plays an important role in abnormal cell proliferation and cancer generation. Murine Double Minute 2 (MDM2) is one of the key negative regulators of p53. p53 reactivation by inhibiting MDM2–p53 interaction represents a promising therapeutic opti...

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Detalles Bibliográficos
Autores principales: Cui, Jingyi, Wang, Yujie, Li, Xiaoxin, Xiao, Fei, Ren, Hongjun, Wu, Meng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10180320/
https://www.ncbi.nlm.nih.gov/pubmed/37175323
http://dx.doi.org/10.3390/molecules28093912

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10180320/
https://www.ncbi.nlm.nih.gov/pubmed/37175323
http://dx.doi.org/10.3390/molecules28093912

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