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Broad responses to chemical adducts shape the natural antibody repertoire in early infancy

Natural antibodies are an integral part of innate humoral immunity yet their development and polyreactive nature are still enigmatic. Here, we show that characteristic monoclonal natural antibodies recognize common chemical moieties or adducts, supporting the view that polyreactive antibodies may of...

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Detalles Bibliográficos
Autores principales: Mashiko, Shunya, Shihab, Ronzon R., See, Sarah B., Schahadat, Luca G. Z., Aguiar, Talita F. M., Roy, Poulomi, Porcheray, Fabrice, Zorn, Emmanuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10181178/
https://www.ncbi.nlm.nih.gov/pubmed/37172087
http://dx.doi.org/10.1126/sciadv.ade8872