CRISPR-Cas9 screen reveals a role of purine synthesis for estrogen receptor α activity and tamoxifen resistance of breast cancer cells

In breast cancer, resistance to endocrine therapies that target estrogen receptor α (ERα), such as tamoxifen and fulvestrant, remains a major clinical problem. Whether and how ERα(+) breast cancers switch from being estrogen-dependent to estrogen-independent remains unclear. With a genome-wide CRISP...

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Detalles Bibliográficos
Autores principales: Hany, Dina, Vafeiadou, Vasiliki, Picard, Didier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10181187/
https://www.ncbi.nlm.nih.gov/pubmed/37172090
http://dx.doi.org/10.1126/sciadv.add3685

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10181187/
https://www.ncbi.nlm.nih.gov/pubmed/37172090
http://dx.doi.org/10.1126/sciadv.add3685

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