Feedback activation of EGFR/wild-type RAS signaling axis limits KRAS(G12D) inhibitor efficacy in KRAS(G12D)-mutated colorectal cancer

Colorectal cancer (CRC), which shows a high degree of heterogeneity, is the third most deadly cancer worldwide. Mutational activation of KRAS(G12D) occurs in approximately 10–12% of CRC cases, but the susceptibility of KRAS(G12D)-mutated CRC to the recently discovered KRAS(G12D) inhibitor MRTX1133 h...

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Detalles Bibliográficos
Autores principales: Feng, Juanjuan, Hu, Zhongwei, Xia, Xinting, Liu, Xiaogu, Lian, Zhengke, Wang, Hui, Wang, Liren, Wang, Cun, Zhang, Xueli, Pang, Xiufeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10181928/
https://www.ncbi.nlm.nih.gov/pubmed/37020035
http://dx.doi.org/10.1038/s41388-023-02676-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10181928/
https://www.ncbi.nlm.nih.gov/pubmed/37020035
http://dx.doi.org/10.1038/s41388-023-02676-9

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