Precise modulation of transcription factor levels identifies features underlying dosage sensitivity

Transcriptional regulation exhibits extensive robustness, but human genetics indicates sensitivity to transcription factor (TF) dosage. Reconciling such observations requires quantitative studies of TF dosage effects at trait-relevant ranges, largely lacking so far. TFs play central roles in both no...

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Detalles Bibliográficos
Autores principales: Naqvi, Sahin, Kim, Seungsoo, Hoskens, Hanne, Matthews, Harold S., Spritz, Richard A., Klein, Ophir D., Hallgrímsson, Benedikt, Swigut, Tomek, Claes, Peter, Pritchard, Jonathan K., Wysocka, Joanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10181932/
https://www.ncbi.nlm.nih.gov/pubmed/37024583
http://dx.doi.org/10.1038/s41588-023-01366-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10181932/
https://www.ncbi.nlm.nih.gov/pubmed/37024583
http://dx.doi.org/10.1038/s41588-023-01366-2

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