Hypoxia switches TET1 from being tumor-suppressive to oncogenic

The classical oxidizing enzymatic activity of Ten Eleven Translocation 1 (TET1) and its tumor suppressor role are well known. Here, we find that high TET1 expression is associated with poor patient survival in solid cancers often having hypoxia, which is inconsistent with its tumor suppressor role....

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Detalles Bibliográficos
Autores principales: Yang, Qi, Dang, Hui, Liu, Jiaxin, Wang, Xingye, Wang, Jingyuan, Lan, Xinhui, Ji, Meiju, Xing, Mingzhao, Hou, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10181935/
https://www.ncbi.nlm.nih.gov/pubmed/37020036
http://dx.doi.org/10.1038/s41388-023-02659-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10181935/
https://www.ncbi.nlm.nih.gov/pubmed/37020036
http://dx.doi.org/10.1038/s41388-023-02659-w

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