Pharmacologic inhibition of HNF4α prevents parenteral nutrition associated cholestasis in mice

Prolonged parenteral nutrition (PN) can lead to PN associated cholestasis (PNAC). Intestinally derived lipopolysaccharides and infused PN phytosterols lead to activation of NFκB, a key factor in PNAC. Our objective was to determine if inhibition of HNF4α could interfere with NFκB to alleviate murine...

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Detalles Bibliográficos
Autores principales: Ghosh, Swati, Devereaux, Michael W., Orlicky, David J., Sokol, Ronald J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10182080/
https://www.ncbi.nlm.nih.gov/pubmed/37173326
http://dx.doi.org/10.1038/s41598-023-33994-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10182080/
https://www.ncbi.nlm.nih.gov/pubmed/37173326
http://dx.doi.org/10.1038/s41598-023-33994-3

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