Unintended CRISPR-Cas9 editing outcomes: a review of the detection and prevalence of structural variants generated by gene-editing in human cells

Genome editing using the clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated protein (Cas) gene-editing system (CRISPR-Cas) is a valuable tool for fundamental and applied research applications. Significant improvements in editing efficacy have advanced genome edi...

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Detalles Bibliográficos
Autores principales: Hunt, John Murray Topp, Samson, Christopher Allan, Rand, Alex du, Sheppard, Hilary M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10182114/
https://www.ncbi.nlm.nih.gov/pubmed/37093294
http://dx.doi.org/10.1007/s00439-023-02561-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10182114/
https://www.ncbi.nlm.nih.gov/pubmed/37093294
http://dx.doi.org/10.1007/s00439-023-02561-1

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