Proteolysis of vaginally administered bovine lactoferrin: clearance, inter-subject variability, and implications for clinical dosing

This report describes proteolytic fragmentation and clearance of bovine lactoferrin (bLF) upon intravaginal administration in premenopausal women. Tablet formulations (MTbLF) containing 300 mg of bLF progressed through three phases: Pre-Dissolution, Dissolution, and Washout, over a 30-h time course....

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Detalles Bibliográficos
Autores principales: Hopp, Thomas P., Matthews, Maura-Ann H., Spiewak, Klaudyna, Athanasiou, Zafeiria, Blackmore, Richard S., Gelbfish, Gary A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10182156/
https://www.ncbi.nlm.nih.gov/pubmed/36580179
http://dx.doi.org/10.1007/s10534-022-00481-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10182156/
https://www.ncbi.nlm.nih.gov/pubmed/36580179
http://dx.doi.org/10.1007/s10534-022-00481-7

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