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Proteolysis of vaginally administered bovine lactoferrin: clearance, inter-subject variability, and implications for clinical dosing
This report describes proteolytic fragmentation and clearance of bovine lactoferrin (bLF) upon intravaginal administration in premenopausal women. Tablet formulations (MTbLF) containing 300 mg of bLF progressed through three phases: Pre-Dissolution, Dissolution, and Washout, over a 30-h time course....
Autores principales: | Hopp, Thomas P., Matthews, Maura-Ann H., Spiewak, Klaudyna, Athanasiou, Zafeiria, Blackmore, Richard S., Gelbfish, Gary A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Netherlands
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10182156/ https://www.ncbi.nlm.nih.gov/pubmed/36580179 http://dx.doi.org/10.1007/s10534-022-00481-7 |
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