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AKT supports the metabolic fitness of multiple myeloma cells by restricting FOXO activity
Metabolic alterations are important cancer-associated features that allow cancer cell transformation and survival under stress conditions. Multiple myeloma (MM) plasma cells show increased glycolysis and oxidative phosphorylation (OXPHOS), which are characteristics associated with recurrent genetic...
Autores principales: | Bloedjes, Timon A., de Wilde, Guus, Khan, Gerarda H., Ashby, Timothy C., Shaughnessy, John D., Zhan, Fenghuang, Houtkooper, Riekelt H., Bende, Richard J., van Noesel, Carel J. M., Spaargaren, Marcel, Guikema, Jeroen E. J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society of Hematology
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10182179/ https://www.ncbi.nlm.nih.gov/pubmed/36322819 http://dx.doi.org/10.1182/bloodadvances.2022007383 |
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