Engineering amino acid uptake or catabolism promotes CAR T-cell adaption to the tumor environment

Cancer cells take up amino acids from the extracellular space to drive cell proliferation and viability. Similar mechanisms are applied by immune cells, resulting in the competition between conventional T cells, or indeed chimeric antigen receptor (CAR) T cells and tumor cells, for the limited avail...

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Detalles Bibliográficos
Autores principales: Panetti, Silvia, McJannett, Nicola, Fultang, Livingstone, Booth, Sarah, Gneo, Luciana, Scarpa, Ugo, Smith, Charles, Vardon, Ashley, Vettore, Lisa, Whalley, Celina, Pan, Yi, Várnai, Csilla, Endou, Hitoshi, Barlow, Jonathan, Tennant, Daniel, Beggs, Andrew, Mussai, Francis, De Santo, Carmela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2022
Materias:
Immunobiology and Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10182289/
https://www.ncbi.nlm.nih.gov/pubmed/36521029
http://dx.doi.org/10.1182/bloodadvances.2022008272

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10182289/
https://www.ncbi.nlm.nih.gov/pubmed/36521029
http://dx.doi.org/10.1182/bloodadvances.2022008272

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